Role of sclrostin (SOST) to predisposing for osteoporosis in β- thalassemia major patients

Sclrostin is a biomarker interrupted in bone resorption process by binding to LRP5 and/or LRP6 family, and prevent Wingless-type signaling (Wnt) which important both development the maintain of mass. Sixty (60) patients with thalassemia major were enrolled from period 2/5/2021 1/9/2021 summer assessment role sclrostin predisposing for osteoporosis β-thalassemia (β-TM). Patients ages (2-40 year) males females they divided children adults had osteopenia."All diagnosed Hb electrophoresis receiving regular blood transfusions anemia chelation therapy prevention iron overload related complications. Detailed history examination including height weight recorded on pre-designed questionnaire samples taken measurement serum"sclrostin level. The results showed non-significant differences (P˃0.05) serum sclerostin (SOST) concentration between beta (β-TM) osteopenia gender, but appeared increased significant male progressive aged.